Close Encounters of the Oily Kind: Regulation of Transporters by Lipids

Table 2

Transporter Regulation by Polyunsaturated Fatty Acidsa

Transporter Fatty acid (structure) Regulationb Ref.
Rat GAT Graphic Transport inhibited 25, 26, 33
Rat GLT-1/GLAST/EAAC1 Arachidonic acid Vmax decreased 25–31, 36
Rat GLT-1 Graphic Vmax decreased 33
Rat EAAT4 Arachidonic acid
 Arachidonic acid I increased, H+ conductance 38
Human EAAT1 Graphic ITransport decreased 35
Human EAAT2 A-Linolenic acid
 Linoleic acid ITransport increased, Km decreased 35
Human EAAT3 Arachidonic acid
 Arachidonic acid
 A-Linolenic acid ITransport increased, Km decreased 35
Human EAAT4 Linoleic acid
 Docosahexanoeic acid
 Oleic acid I increased, H+ conductance 37
Salamander GLT1/GLAST Arachidonic acid
 Oleic acid Vmax decreased 32
Rat DAT Arachidonic acid Transport inhibited
 Vmax decrease, Km decrease 41
Human DAT Arachidonic acid I increased, Cation conductance 42, 44
Rat Na+/K+-ATPase Arachidonic acid Transport inhibited 25

  • ↵a Data reflect effects of fatty acids added to different membrane transport systems in different tissues and species as indicated.

  • ↵b Regulatory effects of the fatty acid addition.

This Article

  1. MI October 2009 vol. 9 no. 5 252-262
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