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Antiangiogenic Drugs: Insights into Drug Development from Endostatin, Avastin and Thalidomide
Table 2
Endogenous Inhibitors of Angiogenesis
| Angioarrestin |
| Angiostatin (plasminogen fragment) |
| Endostatin (collagen fragment) |
| Antiangiogenic antithrombin III |
| Cartilege-derived inhibitor |
| DC59 complement fragment |
| Fibronectin fragment |
| Gro-beta |
| Heparinases |
| Heparin hexasaccharide |
| Human chorionic gonadotropin |
| Pleiotrophin |
| Interferons |
| Interferon inducible protein 10 |
| Interleukin 12 |
| Kringle 5 (plasminogen fragment) |
| Metalloproteinase inhibitors (TIMPs) |
| 2-Methoxyestradiol |
| Placental ribonuclease inhibitor |
| Prostate specific antigen |
| Plasminogen activator inhibitor |
| Platelet factor 4 |
| Prolactin |
| Proliferin-related protein |
| Retinoids |
| Tetrahydrocortisol S |
| Thrombospondin-w |
| Transforming growth factor beta |
| Vasculostatin |
| Vasostatin |
