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Antiangiogenic Drugs: Insights into Drug Development from Endostatin, Avastin and Thalidomide
Table 1
Endogenous Angiogenic Growth Factors
| Placental growth factor |
| Angiopoietin-1 |
| C reactive protein |
| Angiogenin |
| Del-1 |
| Platelet-derived growth factor-BB |
| Fibroblast growth factors: aFGF bFGF |
| Leptin |
| VEGF (aka VPF) |
| Pleiotrophin |
| Follistatin |
| Proliferin |
| Progranulin |
| Granulocyte colony-stimulating factor |
| Midkine |
| Transforming growth factors alpha and beta |
| Hepatocyte growth factor /scatter factor |
| Interleukin-8 |
| Tumor necrosis factor alpha |
| Norepinephrine and epinephrine |
