Diversity of the Neurotoxic Conus Peptides

Table 1.

Examples of Gene Superfamilies

Gene superfamily (Major framework)	Conotoxin families	Target family (mechanism)
A (CC-C-C)	α	Nicotinic receptors (competitive antagonist)
M (CC-C-C-CC)	μ	Na⁺ channels (channel blocker)
	κM	K⁺ channels (channel blocker)
O (C-C-CC-C-C)	ω	Ca²⁺ channels (channel blocker)
	δ	Na⁺ channels (inhibitor of inactivation)
I (C-C-CC-CC-C-C)	ι	Na⁺ channels (activation enhancers)