REGULATION OF DRUG TRANSPORTERS: DURING INFECTION AND INFLAMMATION

Table 3.

Drug Transporter Substrates Affected by Inflammation in Humans

Drug Drug Class Transporter Effect of inflammation Ref.
Cyclosporine Immune modulator Pgp ↑ plasma concentrations (101)
Amitriptyline Anti-depressant Pgp ↑ plasma concentrations; neurotoxicity (102)
Verapamil Calcium channel blocker Pgp ↑ plasma concentrations (103)
Ciprofloxacin Anti-microbial MRP? ↓ clearance (104)
Arbekacin Anti-microbial Pgp ↑ Volume of distribution (105)

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  1. MI April 2007 vol. 7 no. 2 99-111
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