Immunodeficiency Is A Tough Nut to CRAC: The Importance of Calcium Flux in T Cell Activation

Table 1.

Defects in Cytokine Receptors and in Cytokine-Mediated Signaling Leading to SCID^a

		*Lymphocytes Present*
*Disease*	*Genetic defect*	*T cells*	*B cells*
^a Mutations may affect cell-surface expression or ability to transduce proper receptor-driven signals to effector molecules.
γc deficiency	Mutation in γ chain of IL- 2, 4, 7, 9, 15, 21 receptors	−	+
Jak deficiency	Mutation in Jak3 gene	−	+
IL7Rα deficiency	Mutation in IL7RA gene	−	+
CD45 deficiency	Mutation in CD45 gene	−	+
CD3δ	Mutation in CD3D gene	−	+