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Unraveling the Structure of the Variola Topoisomerase IB-DNA Complex: A Possible New Twist on Smallpox Therapy
Table 1.
Topoisomerases Encoded by Nucleocytoplasmic Large Viruses
| Family | Representative Viruses | Topisomerases encoded by virus | Comments | References |
|---|---|---|---|---|
| Poxviridae | Variola (smallpox) and Vaccinia viruses | Type IB | Attacks mammalian (including human) cells | (23) |
| Phycodnaviridae | Chlorella virus | Type II | Attacks green algae | (28) |
| Asfarviridae | African swine fever virus | Type II | Attacks mammalian cells | (29) |
| Iridoviridae | Chilo iridescent virus | Type II | Attacks insect larvae | (30) |
| Mimiviridae | Acanthamoeba polyphaga mimivirus (APMV) | Type IA, IB, and II | Largest known virus in terms of capsid diameter and genome size Attacks Acanthamoeba | (22) |
