The Pharmocogenomics of Warfarin

Table 1.

Non-Synonymous Mutations in VKORC1 Leading to Warfarin Resistance

Amino acid change	Daily Dose	Resistance Phenotype	Reference
Val²⁹ → Leu	14 mg	Moderate	(8)
Ala⁴¹ → Ser	16 mg		(9)
Arg⁵⁸ → Gly	32–36 mg	Major	(8)
Val⁶⁶ → Met	27–35 mg		(29)
Leu¹²⁸ → Arg	> 45 mg	Severe	(8, 30)
Val⁴⁵ → Ala	Target INR never reached		(8)