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Antibody Conjugates and Therapeutic Strategies
Table 1.
Selected Enzymes and Pro-drug Combinations Used in ADEPT Strategies
| Enzyme | Reactivity | Pro-drug | Reference |
|---|---|---|---|
| Alkaline phosphatase | Hydrolysis of phosphate groups | Etoposide | (66) |
| Doxorubicin | (67) | ||
| Phenol mustard | (68) | ||
| Carboxypeptidase G2 | Cleavage between glutamyl moiety and aromatic nucleus | Nitrogen mustards | (14) |
| β-lactamase | Cleavage of lactam ring: elimination of substituents attached to 3′ of cephalosporin derivatives | Doxorubicin | (69) |
| Paclitaxel | (70) | ||
| Mitomycin | (71) | ||
| Cytosine deaminase | Deamination of cytosine to uracil | 5-fluorouracil | (72) |
| Carboxypeptidase A | Cleavage of α-glutamyl peptides | Methotrexate | (73) |
| Antifolates | (74) |
