- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
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Coregulators in Nuclear Estrogen Receptor Action
Table 1.
Coactivators in ER Physiology and Pharmacology
| CoFactor | Full Name | Other Names | Function | Interaction with ER | |
|---|---|---|---|---|---|
| AF-2 Coactivators | SRC-1 (p160) | Steroid receptor coactivator-1 | NCoA-1 | HAT (Histone acetlytranserase) | Binds ERs AF-2 through LXXLL motifs |
| SRC-2 (p160) | Steroid receptor coactivator-2 | GRIP1, TIF-2, NCoA-2 | HAT | Binds ERs AF-2 through LXXLL motifs | |
| SRC-3 (p 160) | Steroid receptor coactivator-3 | AIB1, ACTR, p/CIP, RAC3, TRAM-1, NCoA-3 | HAT | Binds ERs AF-2 through LXXLL motifs | |
| CBP/p300 | CREB-binding protein | HAT | Binds ERs AF-2 through LXXLL motifs | ||
| TRAP220, TRAP/DRIP | Thyroid hormone receptor activating protein of 220 kDa | mediator; PBP | Binds ERs AF-2 through LXXLL motifs | ||
| ASC-1 | Activating signal cointegrator-1 | Bind HATs and NRs | Binds ERs AF-2 through | ||
| ASC-2 | Activating signal cointegrator-2 | RAP250, TRBP, AIB3 | LXXLL motifs | ||
| AF-1 Coactivators | SRA | Steroid receptor activator | Splicing | Binds ERα AF-1 | |
| p68 | p68 RNA helicase | RNA helicase | Binds ERα AF-1 | ||
| Secondary Coactivators | CARM1 | Protein methyltransferase 1 | Arginine histone methyltransferase | Binds ERs AF-2 indirectly through association with p160s | |
| PRMT1 | Protein methyltransferase 1 | Arginine histone methyltransferase | Binds ERs AF-2 indirectly through association with p160s | ||
| CoCoA | Coiled-coil coactivator | Binds ERs AF-2 indirectly through association with p160s | |||
| Dual- Functional Coactivators | E6-AP | E6-associated protein | Ubiquitin ligase | Binds ERs AF-2 | |
| RPF-1 | Receptor potentiating factor-1 | Ubiquitin ligase | Binds ERs AF-2 | ||
| PGC-1α PGC-1β | PPARγ coactivator-1 | Tethering surface for other cofactors; splicing | Binds the hinge region of the ERs | ||
| CAPER-alpha CAPER-beta CoAA | Coactivator of (AP-1) and estrogen receptors Coactivator activator | Potentiate ER activity; splicing | Associate with ER indirectly through binding ASC-2 |
