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NEUROGENIC INFLAMMATION AND MIGRAINE: IMPLICATIONS FOR THE THERAPEUTICS
Table 1.
Three Mechanisms for the Selective Inhibition of Dural PPE
| Agent | Mechanism |
|---|---|
| a Tachykinin receptor 1. | |
| b Endothelin receptor type B. | |
| c Functional designation only; these agents prevent NI-inducing neuropeptide “extravasation” in tregeminal terminals. | |
| Lanepitant (i.e., LY-303870) | |
| GR205171 | |
| L-758298 | |
| FK 888 | TACR1a antagonists |
| Dapitant (i.e., RPR-100893) | |
| Bosentan | EDNRBb antagonist |
| CP-122,288 | |
| 4991W93 | “Extravasation receptor” antagonistsc |
