- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
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Drosophila
Table 3.
Neuroprotective Genes and Compounds Identified Using Drosophila Model
| Gene or Treatment | Affect/Mode of Therapy | Key References |
|---|---|---|
| Ataxin-3 | Ubiquitin protease activity | (52) |
| C2-8 | Reduce PolyQ aggregation | (91) |
| C4 sFv intrabodies | Reduce PolyQ aggregation | (92) |
| CREB-binding protein | Recovery of histone acetylation | (59) |
| dHDJ (HSP 40) | Chaperone activity | (15) |
| dTPR2 | Chaperone activity | (15) |
| Drob-1 | Mitochondrial homeostasis | (93) |
| Geldanamycin | Hsp90 inhibitor | (56, 94) |
| Glutathione S-transferase | Supressor of parkin pathology | (7) |
| Hsp70 | Chaperone activity | (50, 95) |
| SAHA | Histone deactylase inhibitor | (94) |
| SUMO-1 | Reduce PolyQ aggregation | (96) |
| Supressor peptides (3-14 + 3-17) | Supress ND in polyQ | (97) |
| Y-27632 | Inhibits Rho-associated kinase | (98) |
