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Drosophila
Table 2.
Drosophila Neurodegeneration Mutants
| Disease modeled | Affected Protein | Mechanism/Dysfunction | Key References |
|---|---|---|---|
| ATPalpha | Na+K+-ATPase alpha | Ion homeostasis | (27) |
| acd2 [5N18] | Not cloned | ? | (72) |
| benchwarmer | Lysosomal sugar carrier | Endocytic/synaptic | (73) |
| bizarre | Not cloned | ? | (74) |
| blue cheese | Novel Protein | Ubiquitinated protein aggregation | (75) |
| bubblegum | VLCFA acyl–coenzyme A | Adrenoleukodystrophy | (33) |
| cathepsin D | Aspartyl protease | Lysosomal disorder | (76) |
| dADAR | A-to-I RNA editing | Ion homeostasis | (46) |
| dare | Adrenodoxin reductase | Steroid hormone production | (78) |
| dEAAT1 | Excitatory amino acid transport | Excitotoxicity | (30) |
| drop dead | Not cloned | Glial dysfunction | (24) |
| eggroll | Not cloned | ? | (79) |
| futsch | Microtubule-assoc. protein 1B | Axonal transport | (80) |
| löchrig | AMP-activated protein kinase (γ) | Cholesterol homeostasis? | (81) |
| ninaE | Rhodopsin | Retinitis pigmantosa | (82) |
| parg | poly(ADP-ribose)hydrolase | ADP-ribosylation | (83) |
| parkin | Parkin | Mitochondrial impairment | (6) |
| pirouette | Not cloned | ? | (72) |
| rdgA | Diacylglycerol kinase | Phosphatidic acid deficiency | (84, 85) |
| rdgB | Phosphtidyl transporter | G Protein–Coupled Receptor | (86) |
| rdgC | Ser-Thr phosphatase | Rhodopsin phosphatase | (87) |
| sine oculis | Transcription factor | Neuronal connectivity | (88) |
| sniffer | Dehydrogenase/Reductase | Oxidative stress | (89) |
| spongecake | Not cloned | ? | (79) |
| swiss cheese | Neuropathy target esterase | Glial-axonal hyperwrapping | (25) |
| trp | TRP calcium channel | Ion homeostasis | (31) |
| vacuous | Not cloned | Seizure-related | (26) |
| vam | Not cloned | ? | (23) |
| vap | RAS GAP | RAS signaling? | (90) |
| yab sab | Not cloned | ? | (74) |
