- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
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Drosophila
Table 1.
Drosophila Transgenic Models of Neurodegenerative Disease
| Disease Modeled | Affected Protein | Key References |
|---|---|---|
| aPar-1, protease-activated receptor-1. | ||
| bFMR1, Fragile X mental retardation-1. | ||
| Alzheimer | tau | (61) |
| Alzheimer | β-amyloid | (62, 63) |
| Alzheimer | Amyloid precursor protein (APP) | (63) |
| Alzheimer | Presenilin | (63) |
| Alzheimer | BACE (β-site APP-cleaving enzyme) | (63) |
| Alzheimer | PAR-1a | (64) |
| Fragile X | FMR1b (90 rCGG repeats) | (65) |
| Hereditary Spastic Paraplegia | Spastin | (66) |
| Huntington | polyQ | (67) |
| Huntington | Huntingtin | (16) |
| Kennedy | Androgen receptor | (68) |
| Machado-Joseph | Spinocerebellar ataxia type 3 (SCA3) | (18) |
| Neuronal Ceroid Lipfuscinoses | Palmitoyl-protein thioesterase I | (69) |
| Parkinson | α–synuclein | (1, 50, 77) |
| Spinocerebellar Ataxia | SCA1 | (17) |
| Spinal & Bulbar Muscular Atrophy | Androgen receptor | (19) |
| Spinocerebellar Ataxia | SCA8 (Noncoding RNA) | (70) |
| Spinocerebellar Ataxia type 2 | Ataxin-2 SCA2 | (71) |
