Mechanism of Tissue-Selective Drug Action in the Cardiovascular System

Table 2.

Cardiovascular Selectivity^a of Calcium Channel Antagonists

Calcium antagonist	Selectivity
^aSelectivity is defined as the ratio of the IC₅₀ for the antagonist in vascular muscle divided by the IC₅₀ in cardiac muscle; IC₅₀ is the concentration of antagonist necessary for half-maximal inhibition of contraction. [See (29).]
Diltiazem	~1
Verapamil	~1
1,4-Dihydropyridines
Nifedipine	~10
Amlodipine	~10
Felodipine, isradipine,nitrendipine, nicardipine, lacidipine	~100
Nisoldipine	~1000