There Are No Useful CYP3A Probes that Quantitatively Predict the In Vivo Kinetics of Other CYP3A Substrates and No Expectation that One Will Be Found

Table 2.

Spearman Rank Correlations for Relationships Between Five Clearance Values*

	CL_SMidazolam	CL_OMidazolam	CL_STriazolam	CL_OTriazolam
All correlation coefficients (r) were statistically significant at p<0.001 except where noted otherwise. CL _O , oral clearance; CL _S , systemic clearance ¹ Not significant, p=0.11. ² p=0.004. ³ p=0.028. Spearman rank correlations derived from data presented in (2).*
CL_O Alprazolam	0.36¹	0.60²	0.70	0.66
CL_S Midazolam		0.70	0.66	0.48³
CL_O Midazolam			0.77	0.68
CL_S Triazolam				0.71