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NEURONAL PDZ DOMAINS: A Promising New Molecular Target for Inhaled Anesthetics?
Table 1.
Classification of PDZ Domains Based on the C-terminal Sequence of Their Binding Partners
| Class | C-terminal Sequence | Interacting Proteins | Example of PDZ Domain |
|---|---|---|---|
| Φ: Hydrophobic. X: Unspecified | |||
| Class I -X-S/T-X- Φ | ETDV | Shaker K+ channel | PSD-95 (PDZ2) |
| ESDV | NMDAR2A/B | PSD-95 (PDZ2) | |
| TTRV | Neuroligin | PSD-95 (PDZ3) | |
| QSAV | Voltage-gated Na + channel | Syntrophin | |
| DSSL | Protein Kinase Cα | PICK1 | |
| DTRL | β2-adrenergic receptor | NHERF (PDZ1) | |
| SSTL | GKAP or mGluR5 | Shank | |
| Class II -X Φ-X- Φ | SVKI | GluR2 | PICK1, GRIP(PDZ5) |
| EYYV | Neurexin | CASK | |
| EFYA | Syndecan-2 | CASK, Syntenin (PDZ2) | |
| YYKV | Ephrin B1 | PICK1, GRIP(PDZ6) | |
| DVPV | ErbB2 | Erbin | |
| Class III -X-D/E-X- Φ | VDSV | Melatonin receptor | nNOS |
| GEPL | KIF17 | mLIN10,Mint1,X11 | |
| FEEL | Merlin | Syntenin | |
