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Fibrin Mechanisms and Functions in Nervous System Pathology
Table 2.
Fibrin(ogen) Binding Proteins and Biologial Functions
| Binding proteins | Cell type/Site of binding interaction | Function |
|---|---|---|
| IGFBP-3, insulin-like growth factor-1 binding protein 3; bFGF, basic fibroblast growth factor; VEGF, vascular endothelial growth factor; tPA, tissue plasminogen activator; SdrG, serine-aspartate repeat protein G, ClfA, clumping factor A; ClfB, clumping factor B; FnbpA, fibronectin binding protein A; FnbpB, fibronectin binding protein B; Map/Eap, major histocompatibility complex class II analog protein/extracellular adherence protein; Efb, Extracellular fibrinogen binding protein; Emp, extracellular matrix protein-binding protein; M1 and M5 are receptor proteins and virulence factors. | ||
| Mammalian proteins | ||
| Fibronectin | Fibroblasts | Adhesion (47) |
| Migration (48) | ||
| IGFBP-3 | Stromal cells | Migration (50) |
| bFGF (FGF-2) | Endothelial cells | Proliferation (51,52) |
| VEGF | Endothelial cells | Proliferation (53) |
| Thrombin | Plasma | Coagulation (165) |
| Plasminogen | Plasma | Fibrinolysis (34) |
| tPA | Vascular endothelial cells Plasma | Fibrinolysis (34,166) |
| Gelsolin | Plasma | Coagulation (49) |
| Bacterial proteins | ||
| SdrG adhesin | Staphylococcus epidermidis | Adhesion,anti-coagulation (55) |
| ClfA,ClfB,FnbpA, FnbpB adhesins | Staphylococcus aureus | Adhesion (55) |
| Map/Eap,Efb,Emp | Staphylococcus aureus | Anticoagulation (55) |
| M1,M5 | Group A streptococci | Survival (56) |
