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Fibrin Mechanisms and Functions in Nervous System Pathology
Table 1.
Fibrin(ogen) Receptors, Signaling Pathways Induced, and Biological Functions
| Receptors | Recognition site | Cell type/Site of binding interaction | Fibrin(ogen)-Induced Signaling Pathway | Function |
|---|---|---|---|---|
| NF- κB, nuclear factor kappa B; PI3K, phosphoinositide 3-kinase; ERK1/2, extracellular signal-regulated kinase 1 and 2; PLC, phospholipase C; ICAM-1, intercellular adhesion molecule 1. | ||||
| Integrins | ||||
| α5β1 | Aα572–574 | Leukocytes | - | Migration (120 |
| Endothelial cells | Adhesion (147) | |||
| αMβ2 | γ190–202 | Neutrophils | NF-κB (148) | Adhesion (150) |
| Migration (151, 152) | ||||
| (Mac-1, CD11b/ CD18) | γ377–395 | |||
| Monocytes | PI3K (41) | Survival (41) | ||
| ERK1/2 (41, 149) | Cytokine release (42 | |||
| Phagocytosis (149) | ||||
| αIIbβ3 | γ400–411 | Platelets, | PLC | Adhesion (39, 153) |
| γ365–383 | Megakaryocytes | |||
| αvβ3 | Aα572–574 | Endothelial cells | PLC | Adhesion (154) |
| Fibroblasts | Adhesion (155) | |||
| αIIbβ8 | - | Schwann cells | ERK1/2 (66) | Adhesion (74) |
| (73, 74) | Proliferation (66) | |||
| Non-Integrins | ||||
| ICAM-1 | γ117–133 | Leukocytes | Adhesion (157–160) | |
| Neutrophils | Rho (156) | Migration (43) | ||
| Endothelial cells | ERK1/2 (45) | Survival (45) | ||
| VE-cadherin | β15–42 | Endothelial cells | - | Adhesion (161) |
| Proliferation (162) | ||||
| Migration (163, 164) | ||||
| Capillary tube formation (46, 163) | ||||
