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Probing the World of Cytochrome P450 Enzymes
Table 3.
Selected Nonsynonymous Polymorphisms in CYP Enzymes and the Functional Consequence
| Enzyme | Common Allelic Variant | Amino Acid Substitution | Effect on Enzyme Function |
|---|---|---|---|
| CYP2A6 | CYP2A6*2 | Leu160His | Decreased |
| CYP2B6 | CYP2B6*5 | Arg487Cys | Unchanged |
| CYP2B6*6 | Gln172His, Lys262Arg | Increased | |
| CYP2B6*7 | Gln172His, Lys262Arg, Arg487Cys | Increased | |
| CYP2C8 | CYP2C8*2 | Ile269Phe | Decreased |
| CYP2C8*3 | Arg139Lys, Lys399Arg | Decreased | |
| CYP2C9 | CYP2C9*2 | Arg144Cys | Altered affinity |
| CYP2C9*3 | Ile359Leu | Decreased | |
| CYP2C9*5 | Asp360Glu | Decreased | |
| CYP2D6 | CYP2D6*10 | Pro34Ser, Ser486Thr | Decreased |
| CYP2D6*17 | Thr107Ile, Arg296Cys, Ser486Thr | Decreased | |
| CYP2E1 | CYP2E1*2 | Arg76His | Decreased |
