Probing the World of Cytochrome P450 Enzymes

Table 2.

Selected In Vitro and In Vivo Probe Substrates for CYP Enzymes

CYP Probe Substrate In Vitro In Vivo
CYP1A2 Phenacetin Caffeine
CYP2A6 Coumarin Courmarin
CYP2B6 Bupropion Bupropion
CYP2C8 Paclitaxel Unclear
CYP2C9 Diclofenac Tolbutamide S-Warfarin Tolbutamide S-Warfarin
CYP2C19 S-Mephenytoin Omeprazole S-Mephenytoin Omeprazole
CYP2D6 Bufurolol Dextromethrophan
CYP2E1 Chlorzoxazone Chlorzoxazone
CYP3A4 Midazolam Testosterone Midazolam Erythromycin

This Article

  1. MI June 2004 vol. 4 no. 3 157-162
  1. AbstractFree
  2. Full Text
  3. Full Text (PDF)

Current Issue

  1. April 2011, 11 (2)
  1. Current Issue
  1. Alert me to new issues of MI
Society Logo HighWire Press Logo CLOCKSS logo