Probing the World of Cytochrome P450 Enzymes

Table 1.

Representative Listing of Substrates for CYP Enzymes

Enzyme	Representative Substrates
CYP1A2	Caffeine, clozapine, .uvoxamine, theophylline, R-warfarin
CYP2A6	Coumarin, nicotine
CYP2B6	Bupropion, cyclophosphamide, efavirenz, S-mephenytoin
CYP2C8	Amiodarone, chloroquine, paclitaxel, repaglinide, retinoic acid
CYP2C9	Diclofenac, .urbiprofen, glipizide, glyburide, ibuprofen, losartan, naproxen, phenytoin, tolbutamide, S-warfarin
CYP2C19	Citalopram, cyclophosphamide, diazepam, imipramine, lansoprazole, omeprazole, pantoprazole, S-mephenytoin, voriconazole
CYP2D6	Amitriptyline, carvedilol, codeine, desipramine, dextromethorphan, .uoxetine, .uvoxamine, haloperidol, metoprolol, nortriptyline, paroxetine, tolterodine, venlafaxine
CYP2E1	Acetaminophen, chlorzoxazone, ethanol, inhalational anesthetics
CYP3A4/5	Alfentanyl, alprazolam, amlodipine, atorvastatin, buspirone, cisapride, clarithromycin, cortisol, cyclosporine, diltiazem, erythromycin, estradiol, felodipine, fentanyl, .nasteride, haloperidol, hydrocortisone, imatinib, indinavir, irinotecan, lidocaine, lovastatin, methadone, midazolam, nelfinavir, nifedipine, nisoldipine, nitrendipine, odanestron, paclitaxel, progesterone, quinidine, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, tacrolimus, tamoxifen, testosterone, triazolam, verapamil, vincristine, zaleplon, zolpidem