Biochemical Mechanisms of Cyclosporine Neurotoxicity

Table 4.

Cyclosporine Concentrations in Rat Brain, Brain Slices, and Mitochondria

Rats were treated with 10 mg/kg/day cyclosporine for 6 days, and rat brain slices were perfused with different cyclosporine concentrations for 4 hours. Data gathered from (15–17).
Cyclosporine blood concentrations [ng/ml]	Cyclosporine in the brain [ng/g]	Cyclosporine in brain mitochondira [ng/g]
409±133	222±35	68.3±14.8
Cyclosporine in the perfusion medium [ng/ml]	Cyclosporine in brain slices [ng/g]	Cyclosporine in brain mitochondria [ng/g]
100	65±13	51±13
500	208±31	81±27
5000	1240±201	589±241