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Transgenic Analysis of Human Drug–Metabolizing Enzymes: Preclinical Drug Development and Toxicology
Table 4.
Other DME Gene Deletions
| Gene | Phenotype | Genetic Background | Comments | Citation |
|---|---|---|---|---|
| GstP | None | 129xMF1 | Protection against DMBA toxicity | (28, 30) |
| or | ||||
| C57BL/6 | Protection against acetaminophen toxicity | |||
| NQO-1 | None | 129xC57BL/6 | Increased menadione toxicity Myelogenous hyperplasia | (32) |
| mEH | None | 129xC57BL/6 | Protection against DMBA toxicity | (34) |
| sEH | Lowered systolic blood pressure (males) | 129xC57BL/6 | Altered renal arachidonic acid metabolism (males and females) | (35) |
| GPx | None | 129xC57BL/6 | Increased sensitivity to Diquat | (36) |
| GCLM | None | 129xC57BL/6 | Depleted GSH levels in liver, lung, pancreas and plasma | (40) |
