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Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease
Table 1.
Tissue-Specific Effects of Selected SERMs
| Breast | Uterus | Vasculature | ||
|---|---|---|---|---|
| Indirect effect | Direct effect | |||
| Tamoxifen | - | + | Lowers total cholesterol, | ? |
| no effect on HDL | ? | |||
| GW5638 | - | - | Lowers total cholesterol | ? |
| EM-800 | - | - | Lowers total cholesterol | NO-mediated vasodilation |
| and triglycerides | ||||
| Raloxifene | - | - | Lowers total cholesterol | NO-mediated vasodilation |
| and triglycerides, | ROS reduction | |||
| no effect on HDL | ||||
| LY117018 | ? | - | Lowers total cholesterol | NO-mediated vasodilation |
