LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing

Table 1.

LXR Regulation of Genes Involved in Lipid Metabolism

Target Gene	Target Tissues	Function	LXRE	Species	References
N/A: LXRE has not been identified yet.
			→→
CYP7A1	liver	bile acid synthesis	TGGTCActcaAGTTCA	rat	4, 8, 14
			TGGTCAcccaAGTTCA	mouse
			TGGTCAtccaAGTTCA	hamster
			TTGTCAaccaAGCTCA	human

ABCA1	macrophage	cholesterol efflux	AGGTTActatCGGTCA	human	12, 20– 22
	intestine		GGATCAcctgAGGTCA
			AGATCActtgAGGTCA
			AGGTTActgaAGGCCA

ABCG5/G8	liver, intestine	sterol transport	N/A		24, 59

ABCG1	macrophage	cholesterol efflux	TGGTCActcaAGTTCA	human	29, 31
			AGTTTAtaatAGTTCA

APOE	macrophage	component of lipoprotein particles	GGGTCActggCGGTCA	human	34
	adipocyte		GAATCActtaAGGTCA

LPL	liver	triglyceride hydrolysis	AGGTCAccacCGGTCA	mouse	37, unpublished
	macrophage		AGGTGActgcAGGTCA	human	observation

CETP	-	cholesterol ester transfer	GGGTCAttgtCGGGCA	human	36

SREBP-1c	liver, fat	fatty acid synthesis	GGGTTActggCGGTCA	mouse	42– 44
	intestine		GGGTTActagCGGGCG

LXRα	macrophage	cholesterol sensor	AGGTTActgcTGGTCA	human	51, 52

YZ-2	liver	pyrimidine metabolism (?)	N/A		unpublished
					observation