Expression Array Technology in the Diagnosis and Treatment of Breast Cancer

Table 1.

Gene Expression Associated with Estrogen Receptor- Positive Tumors^a

Gene name	Gene symbol	Published gene list^b
		(12)	(13)	(14)	(15)	(16)
^a Data represent gene expression statistically associated with estrogen receptor (ER) positive tumors in at least three independent studies.
^b See references.
^c NM = not mentioned in study.
^d + = positive correlation with estrogen receptor positive tumors, but this gene defines a poorer prognosis group (Luminal B tumors) than the other markers (which define the more favorable Luminal A tumors).
estrogen receptor 1	ESR1	+	NM^c	+	+	+
GATA-binding protein 3	GATA3	+	+	+	+	+
hepatocyte nuclear factor 3, alpha	HNF3A	+	NM	NM	+	+
trefoil factor 3	TFF3	+	+	+	+	+
insulin-like growth factor 2	IGF2	+	+	+	+	+
(somatomedin A)
N-acetyltransferase 1	NAT1	+	NM	+	+	+
(arylamine N-acetyltransferase)
X-box binding protein 1	XBP1	+	+	NM	+	+
LIV-1 protein, estrogen regulated	LIV-1	+	NM	NM	+	+
fructose-1,6-bisphosphatase 1	FBP1	NM	NM	+	+	+
v-myb oncogene	MYB	+^d	+	NM	+	+
homolog (avian)