Comparisons Between RELN-and DNMT1-Positive Neuronal Counts in Prefrontal Cortex (Brodmann area 10)
| Layer | mRNA | Mean | ||
|---|---|---|---|---|
| NPS | SP | ANOVA | ||
| Data show the mean numbers of RELN or DNMT positive neurons in non-psychiatric subjects (NPS) and schizophrenia patients (SP). The in situ hybridization was performed on tissue that had a post-mortem interval (PMI) of between 5 and 7 hr. ANOVA=NPS vs SP: Cell number = #/mm2 x 10−3; NS = there is no statistically significant difference between groups: groups include 3 NPS and 7 SP. | ||||
| For details of in situ hybridization histochemical methods, see (46). | ||||
| I | Reelin | 1.87 | 0.72 | <.001 |
| Dnmt 1 | 1.13 | 1.74 | <.001 | |
| II | Reelin | 2.63 | 1.17 | <.001 |
| Dnmt 1 | 2.23 | 3.37 | <.002 | |
| III | Reelin | 1.63 | 0.79 | <.001 |
| Dnmt 1 | 2.03 | 2.94 | NS | |
| IV | Reelin | 1.57 | 1.10 | <.028 |
| Dnmt 1 | 2.23 | 3.60 | <.018 | |
| V | Reelin | 1.53 | 1.03 | <.001 |
| Dnmt 1 | 1.77 | 2.84 | <.040 | |
| VI | Reelin | 1.37 | 1.07 | <.010 |
| Dnmt 1 | 2.30 | 3.23 | NS | |
| PMI (hr) | 6.6 | 6.14 | NS | |