- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
- Sign In as Member / Individual
Inhibition of Nuclear Factor Kappa B (NF-B):
Table 1.
NF-kB Inhibitors that Demonstrate Anti-Inflammatory Activity in Experimental Models
| Classa | In vitro | In vivo |
|---|---|---|
| aAn extensive collection of drugs that range widely in structure and activity are now known to inhibit NF-κB activity, and more importantly, they alleviate inflammation in pharmacologically relevant in vivo models. Unfortunately, many of these drugs display significant and harmful side effects, and so the identification of safer, selective inhibitors of NF-κB activation remains a major goal for many pharmaceutical and biotechnology companies. | ||
| bODNs, oligodeoxynucleotides | ||
| CTFD, transcription factor decoy | ||
| Salicylates aspirin, sulfasalazine, triflusal | Synovial fibroblast, lung epithelial cells, dendritic cells, monocytes, macrophages, T-cells, endothelial cells, vascular smooth muscle cells. | Contact hypersensitivity, zymosan-induced paw inflammation |
| NSAIDs ibuprofen, sulindac, tepoxalin | Macrophages, endothelial cells, T-cells | Zymosan-induced inflammation in the paw and spinal cord |
| Glucocorticoids dexamethasone, hydrocortisone | Macrophages, endothelial cells, pulmunory epithelial cells, T-cells | Carrageenin-induced air pouch, peritoneal sepsis, myocardial contractile depression |
| Antisense ODNsb anti-p50, anti-p65 | Fibroblast, B-cells, T-cells | Graft rejection, septic shock |
| TFDC-ODNs | Endothelial cells, vascular smooth muscle cells, macrophages | Rheumatoid arthritis, ischemia-reperfusion injury, nephritis, carrageenin-induced paw inflammation, Arthus reaction |
| Natural compounds flavanoids, polyphenols, sesquiterpene lactones, curcumin, sesterterpene | T-cells, macrophages, fibrosarcoma and epithelial cells | Septic shock, TPA-induced skin inflammation |
| Antioxidants PDTC, N-acetylcysteine, Vitamin E, Vitamin C | Macrophages, monocytes, T-cells | Septic shock, neutrophilic alveolitis, multiple organ injury, experimental allergic encephalomyelitis |
| Proteasome inhibitors lactacystin, MG132, TLCK, TPCK, PSI, PS-519, PS-341 | Macrophages, monocytes, T-cells, B-cells | Asthma, septic shock, neutrophilic alveolitis, cerebral and myocardial ischemia-reperfusion injury |
| Peptides SN50, NLS, NBD, TIRAP | Macrophages, T-cells, endothelial cells, vascular smooth cells | Septic shock, zymosan-induced peritonitis, PMA-induced ear edema, carrageenin-induced paw inflammation, Arthus reaction, inflammatory bowel disease |
