- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
- Sign In as Member / Individual
The Deorphanization of TRPV1 and the Emergence of Octadecadienoids as a New Class of Lipid Transmitters
Table 1
Putative Endogenous TRPV1 Agonists
| Compound | Structure | Approximate ED50 as TRPV1 Agonists | Efficacy Relative to Capsaicin In Vitro | Reference |
|---|---|---|---|---|
| Arachidonoyl ethanolamide (Anandamide) |  |
1 – 30 μM1 | Less | (10) |
| 0.5 – 5 μM2 | Less | (12) | ||
| N-arachidonoyl- dopamine |  |
50 nM2 | ~ Equal | (12) |
| 9-hydroxyoctadecadienoic acid (9-HODE) |  |
300 nM1 | Less | (4) |
| 13-hydroxyoctadecadienoic acid (13-HODE) |  |
800 nM3 | Less | (4) |
| 12-hydroperoxyeicosatetraenoic acid (12-(S)-HPETE |  |
8 μM1 | Less | (11) |
| 15-hydroperoxyeicosatetraenoic acid (15-(S)-HPETE) |  |
9 μM1 | Less | (11) |
| N-oleoyl-dopamine |  |
36 nM3 | ~ Equal | (13) |
