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Networking with AKAPs
Table 1
Nomenclature and Subcellular Localization for AKAPs, Splice Variants, Isoforms, Orthologs, and Associating Molecules
| AKAP | Associating Molecules | Targeting Motifs/Localization | References | |
|---|---|---|---|---|
| AKAP-Lbc | PKD | α-Catulin | Actin cytoskeleton cytoplasm | (51–55, 57–60, 87, 88) |
| Brx | PKCη | |||
| proto-Lbc | Rho | |||
| Onco-Lbc | 14-3-3 | |||
| AKAP13 | LC3 | |||
| AKAP18 (α, β, γ, δ) | CaV1.1/1.2 | AQP2 | Plasma membrane (α and β myristoylation, dual palmitoylation) | (89–97) |
| AKAP15 | PLB | NaV1.2a | ||
| AKAP7 | PDE4D | 5’-AMP | Cytosolic and nuclear (γ and δ NLS) | |
| AKAP79 | PKC | β1-AR | Plasma membrane (Polybasic domain interaction with PIP2) | (15, 17, 61–64, 74, 76, 83, 88–108) |
| AKAP150 | GluR1 | SAP97 | ||
| AKAP75 | mGluR1/5 | PSD-95 | Postsynaptic densities (SAP97) | |
| AKAP5 | AC5/6 | PP2B | ||
| KCNQ2 | CaV1.2 | |||
| Kir2.1 | ASIC1a/2a | |||
| TRPV1 | NMDAR | |||
| IQGAP1 | ||||
| mAKAP | PDE4D3 | RyR | Nuclear envelope (Nesprin-1α) | (80, 109–117) |
| AKAP100 | Nesprin-1α | NCX | Sarcoplasmic reticulum (RyR) | |
| AKAP6 | Epac | MEK/ERK5 | ||
| PDK1 | AC5 | |||
| Siah2 | HIF-1α | |||
| VHL | ||||
| Gravin (α,β,γ) | PKC | Myristoylated | (118–124) | |
| AKAP250 | β2-AR | Membrane | ||
| AKAP12 | CyclinD | Cytoskeleton | ||
| D-AKAP1 | PP1 | RSK1 | Mitochondria | (14, 125–136) |
| AKAP84 | PTPD1 | PP2Ac | Endoplasmic reticulum | |
| S-AKAP84 | Lamin B | |||
| AKAP121 | PDE7A | |||
| AKAP140 | AMY-1 | |||
| AKAP149 | HIV-1 RT | |||
| AKAP1 | mRNA | |||
| CG-NAP | PP1 | PKN | Centrosome (PACT domain) | (19–21, 137) |
| Yotiao | NMDAR | GCP2/3 | Golgi | |
| Hyperion | KCNQ1 | CLIC | Plasma membrane | |
| AKAP350 | IP3R | PP2A | ||
| AKAP450 | PKCɛ | |||
| AKAP120 | CK1 | |||
| AKAP9 | PDE4D3 | |||
| Rab32 | Varp | CD44 | Myofilaments | (138–141) |
| ICAM-1/2 | ||||
| RhoGDI | ||||
| S100P | ||||
| WWOX | ||||
| Myospryn | Desmin | Dystrophin | N-Terminal prenylation | (142–144) |
| Dysbindin | ||||
| Pericentrin | PKC | Tubulin | Centrosome (PACT domain) | (34, 145–147) |
| MAP2 | Tubulin | Myosin VIIa | Microtubules | (98, 148–153) |
| A,B,C,D | F-actin | Fyn | ||
| Src | CaV1.2 | |||
| Grb2 | ||||
| AKAP220 | PP1 | GABACR | Vesicles | (154–159) |
| AKAP11 | GSK3β | AQP2 | ||
| Ezrin | CFTR | Actin cytoskeleton | (160–166) | |
| AKAP78 | EBP50 | |||
| EZR | NHERF | |||
| FAK | ||||
| Merlin | ||||
| AKAP95 | Condensin | p68 RNA | Nuclear matrix | (129, 132, 166–170) |
| AKAP8 | PDE7A | helicase | ||
| AMY-1 | MCM2 | |||
