DNA DAMAGE-INDUCED MUTAGENESIS

Table 1.

Translesion specificity of human Polη, Polι, and Polκ

DNA lesion	Polη	Polι	Polκ
^a -, activity is generally below detection.
^b ND, not determined.
3' T of TT dimer	A	T>G>A	-^a
5' T of TT dimer	A	-	ND^b
3' T of TT (6-4)	G>A>T	A>T	-
5' T of TT (6-4)	-	-	ND
8-oxoG	C ≃ A	C>A	A>C
AP site	A>G>C>T	G>T>A>C	A
AAF-G	C	C	T ≃ C>A
anti-BPDE-N²-dG	A>T>G ≃ C	ND	C