- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
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Pharmacology of Capacitative Calcium Entry
Table 1.
Inhibitors ofCapacitativeCalciumEntry
| Inhibitor type | Examples | Ki (μM) |
|---|---|---|
| Cations | Lanthanides | 10 – 100 |
| Gd3+ | ≤1 | |
| Divalent cations | 1000-5000 | |
| P-450 inhibitors | Econazole | 0.2-10 |
| Miconazole | 0.5-1 | |
| Clotrimazole | 2-20 | |
| Ketoconazole | 15-80 | |
| Cyclooxygenase inhibitors | Niflumic acid | 150 |
| Flufenamic acid | 33 | |
| Tenidap | 13.5 | |
| Lipoxygenase inhibitors | Nordihydroguaiaretic acid | 12 |
| Eicosatetraynoic acid | 4 | |
| Channel blockers (putative) | SK&F 96365 | 3-48 |
| SC38249 | 13 | |
| LU52396 | 2 | |
| L-651,582 | 1.2 | |
| Tetrandrine | 20 | |
| 2-APB | 30 | |
| Mechanism-based inhibitors | U73122 (phospholipase C inhibitor) | 10 |
| Wortmannin (phosphatidylinositol kinase inhibitor) | 10 |
